Publications and Presentations

Huang W, Yu J, Farese AM, MacVittie TJ, Kane MA. Acute Proteomic Changes in Non-human Primate Kidney after Partial-body Radiation with Minimal Bone Marrow Sparing. Health Phys. 2021 Oct 1;121(4):345-351. doi: 10.1097/HP.0000000000001475. PMID: 34546216.

Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M. Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination. J Cell Biol. 2021 Jun 7;220(6):e202006043. doi: 10.1083/jcb.202006043. PMID: 33851959; PMCID: PMC8050842.

Huang W, Yu J, Liu T, Defnet AE, Zalesak-Kravec S, Farese AM, MacVittie TJ, Kane MA. Acute Proteomic Changes in Lung after Radiation: Toward Identifying Initiating Events of Delayed Effects of Acute Radiation Exposure in Non-human Primate after Partial Body Irradiation with Minimal Bone Marrow Sparing. Health Phys. 2021 Oct 1;121(4):384-394. doi: 10.1097/HP.0000000000001476. PMID: 34546219; PMCID: PMC8546870.

Kumar P, Wang P, Farese AM, MacVittie TJ, Kane MA. Metabolomics of Multiorgan Radiation Injury in Non-human Primate Model Reveals System-wide Metabolic Perturbations. Health Phys. 2021 Oct 1;121(4):395-405. doi: 10.1097/HP.0000000000001472. PMID: 34546220.

Muller L, Huang W, Jones JW, Farese AM, MacVittie TJ, Kane MA. Complementary Lipidomic, Proteomic, and Mass Spectrometry Imaging Approach to the Characterization of the Acute Effects of Radiation in the Non-human Primate Mesenteric Lymph Node after Partial-body Irradiation with Minimal Bone Marrow Sparing. Health Phys. 2021 Oct 1;121(4):372-383. doi: 10.1097/HP.0000000000001470. PMID: 34546218.

Zalesak-Kravec S, Huang W, Wang P, Yu J, Liu T, Defnet AE, Moise AR, Farese AM, MacVittie TJ, Kane MA. Multi-omic Analysis of Non-human Primate Heart after Partial-body Radiation with Minimal Bone Marrow Sparing. Health Phys. 2021 Oct 1;121(4):352-371. doi: 10.1097/HP.0000000000001478. PMID: 34546217; PMCID: PMC8554778.

Yu J, Huang W, Liu T, Defnet AE, Zalesak-Kravec S, Farese AM, MacVittie TJ, Kane MA. Effect of Radiation on the Essential Nutrient Homeostasis and Signaling of Retinoids in a Non-human Primate Model with Minimal Bone Marrow Sparing. Health Phys. 2021 Oct 1;121(4):406-418. doi: 10.1097/HP.0000000000001477. PMID: 34546221; PMCID: PMC8549574.

Morrison KE, Stenson AF, Marx-Rattner R, Carter S, Michopoulos V, Gillespie CF, Powers A, Huang W, Kane MA, Jovanovic T, Bale TL. Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures. Biol Psychiatry. 2021 Aug 17:S0006-3223(21)01521-3. doi: 10.1016/j.biopsych.2021.08.003. Epub ahead of print. PMID: 34715991.

Stokum JA, Shim B, Huang W, Kane M, Smith JA, Gerzanich V, Simard JM. A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain. J Cereb Blood Flow Metab. 2021 Oct;41(10):2546-2560. doi: 10.1177/0271678X211004182. Epub 2021 Apr 4. PMID: 33818185; PMCID: PMC8504955.

Tran A, Monreal IA, Moskovets E, Aguilar HC, Jones JW. Rapid Detection of Viral Envelope Lipids Using Lithium Adducts and AP-MALDI High-Resolution Mass Spectrometry. J Am Soc Mass Spectrom. 2021 Sep 1;32(9):2322-2333. doi: 10.1021/jasms.1c00058. Epub 2021 Apr 22. PMID: 33886294.

Carballal S, Vitvitsky V, Kumar R, Hanna DA, Libiad M, Gupta A, Jones JW, Banerjee R. Hydrogen sulfide stimulates lipid biogenesis from glutamine that is dependent on the mitochondrial NAD(P)H pool. J Biol Chem. 2021 Aug;297(2):100950. doi: 10.1016/j.jbc.2021.100950. Epub 2021 Jul 10. PMID: 34252456; PMCID: PMC8342795.

Defnet AE, Shah SD, Huang W, Shapiro P, Deshpande DA, Kane MA. Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma. FASEB J. 2021 Dec;35(12):e22016. doi: 10.1096/fj.202100835R. PMID: 34784434.

Sha Z, Montano MM, Rochon K, Mears JA, Deredge D, Wintrode P, Szweda L, Mikita N, Lee I. A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease. Arch Biochem Biophys. 2021 Oct 15;710:108983. doi: 10.1016/j.abb.2021.108983. Epub 2021 Jul 3. PMID: 34228963.

Yang N, Parker LE, Yu J, Jones JW, Liu T, Papanicolaou KN, Talbot CC Jr, Margulies KB, O'Rourke B, Kane MA, Foster DB. Cardiac retinoic acid levels decline in heart failure. JCI Insight. 2021 Apr 22;6(8):e137593. doi: 10.1172/jci.insight.137593. PMID: 33724958; PMCID: PMC8119182.

Martinez R 3rd, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P. Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress. J Pharmacol Exp Ther. 2021 Jan;376(1):84-97. doi: 10.1124/jpet.120.000266. Epub 2020 Oct 27. PMID: 33109619; PMCID: PMC7788356.

Kinney CJ, O'Neill A, Noland K, Huang W, Muriel J, Lukyanenko V, Kane MA, Ward CW, Collier AF, Roche JA, McLenithan JC, Reed PW, Bloch RJ. μ-Crystallin in Mouse Skeletal Muscle Promotes a Shift from Glycolytic toward Oxidative Metabolism. Curr Res Physiol. 2021 Feb 9;4:47-59. doi: 10.1016/j.crphys.2021.02.003. PMID: 34746826; PMCID: PMC8562245.

Dubey A, Yu J, Liu T, Kane MA, Saint-Jeannet JP. Retinoic acid production, regulation and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification. Development. 2021 Feb 16;148(4):dev193227. doi: 10.1242/dev.193227. PMID: 33531433; PMCID: PMC7903997.

Stojan G, Li J, Liu T, Kane MA, Petri MA. Intracellular homocysteine metabolites in SLE: plasma S-adenosylhomocysteine correlates with coronary plaque burden. Lupus Sci Med. 2021 Jan;8(1):e000453. doi: 10.1136/lupus-2020-000453. PMID: 33479047; PMCID: PMC7825256.

Morel Y, Hegdekar N, Sarkar C, Lipinski MM, Kane MA, Jones JW. Structure-specific, accurate quantitation of plasmalogen glycerophosphoethanolamine. Analytica Chimica Acta, Volume 1186, 2021, https://doi.org/10.1016/j.aca.2021.339088.

Lee JG, Huang W, Lee H, van de Leemput J, Kane MA, Han Z. Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor. Cell Biosci 11, 58 (2021). https://doi.org/10.1186/s13578-021-00568-7

Huang W, and Kane MA. MAPLE: A Microbiome Analysis Pipeline Enabling Optimal Peptide Search and Comparative Taxonomic and Functional Analysis. J. Proteome Res. 2021, 20, 5, 2882–2894. https://doi.org/10.1021/acs.jproteome.1c00114

Brandis JEP, Zalesak SM, Kane MA, Michel SLJ. Cadmium Exchange with Zinc in the Non-Classical Zinc Finger Protein Tristetraprolin. Inorg. Chem. 2021, 60, 11, 7697–7707. https://doi.org/10.1021/acs.inorgchem.0c03808

Pritts JD, Oluyadi AA, Huang W, Shimberg GD, Kane MA, Wilks A, Michel SLJ. Understanding RNA Binding by the Nonclassical Zinc Finger Protein CPSF30, a Key Factor in Polyadenylation during Pre-mRNA Processing. Biochemistry 2021, 60, 10, 780–790. https://doi.org/10.1021/acs.biochem.0c00940

Brandis JEP, Kihn KC, Taraban MB, Schnorr J, Confer AM, Batelu S, Sun D, Rodriguez JD, Jiang W, Goldberg DP, Langguth P, Stemmler TL, Yu YB, Kane MA, Polli JE, Michel SLJ. Evaluation of the Physicochemical Properties of the Iron Nanoparticle Drug Products: Brand and Generic Sodium Ferric Gluconate. Mol. Pharmaceutics 2021, 18, 4, 1544–1557. https://doi.org/10.1021/acs.molpharmaceut.0c00922

Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, Tan TP, Smith KH, Cronin T, Martin OA, Sanders ME, Lucan SC, Kane MA. Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients, 13(8), 2814. 2021 Aug 17. https://doi.org/10.3390/nu13082814

Kelly DL, Kane MA, Fraser CM, Sayer MA, Grant-Beurmann S, Liu T, Gold JM, Notarangelo FM, Vyas GR, Richardson CM, August SM, Kotnana B, Miller J, Liu F, Buchanan RW. Prebiotic Treatment Increases Serum Butyrate in People With Schizophrenia: Results of an Open-Label Inpatient Pilot Clinical Trial. J Clin Psychopharmacol. 2021 Mar-Apr 01;41(2):200-202. doi: 10.1097/JCP.0000000000001364. PMID: 33587401.

Srikanth MP, Jones JW, Kane M, Awad O, Park TS, Zambidis ET, Feldman RA. Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1. Stem Cells Transl Med. 2021 Jul;10(7):1081-1094. doi: 10.1002/sctm.20-0386. Epub 2021 Mar 3. PMID: 33656802; PMCID: PMC8235124.

Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Park S, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 2021 May 12;29(5):777-791.e6. doi: 10.1016/j.chom.2021.03.003. Epub 2021 Apr 1. PMID: 33798492; PMCID: PMC8122070.

Hudson KM, Shiver E, Yu J, Mehta S, Jima DD, Kane MA, Patisaul HB, Cowley M. Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior. Sci Rep. 2021 Aug 11;11(1):16302. doi: 10.1038/s41598-021-95630-2. PMID: 34381081; PMCID: PMC8357970.

MacVittie TJ, Farese AM, Kane MA. Animal Models: A Non-human Primate and Rodent Animal Model Research Platform, Natural History, and Biomarkers to Predict Clinical Outcome. Health Phys. 2021 Oct 1;121(4):277-281. doi: 10.1097/HP.0000000000001479. PMID: 34546212; PMCID: PMC8462056.

Nelson CE, Huang W, Zygiel EM, Nolan EM, Kane MA, Oglesby AG. The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa. Microbiol Spectr. 2021 Oct 31;9(2):e0051921. doi: 10.1128/Spectrum.00519-21. Epub 2021 Sep 22. PMID: 34549997; PMCID: PMC8557868.

Shimada BK, Boyman L, Huang W, Zhu J, Yang Y, Chen F, Kane MA, Yadava N, Zou L, Lederer WJ, Polster BM, Chao W. Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study Of Mitochondrial Proteome. Shock. 2021 Sep 9. doi: 10.1097/SHK.0000000000001858. Epub ahead of print. PMID: 34506367.

Kumar P, Wang P, Tudor G, Booth C, Farese AM, MacVittie TJ, Kane MA. Evaluation of Plasma Biomarker Utility for the Gastrointestinal Acute Radiation Syndrome in Non-human Primates after Partial Body Irradiation with Minimal Bone Marrow Sparing through Correlation with Tissue and Histological Analyses. Health Phys. 2020 Nov;119(5):594-603. doi: 10.1097/HP.0000000000001348. PMID: 32947487; PMCID: PMC7546578.

Stefanak MP, Al-Mudares F, El-Metwally D, Jones JW, Kane MA, Bearer CF. High concentrations of urinary ethanol metabolites in neonatal intensive care unit infants. Pediatr Res. 2020 Dec;88(6):865-870. doi: 10.1038/s41390-020-1020-5. Epub 2020 Jun 20. PMID: 32563185.

Rajakumar A, Kane MA, Yu J, Jones JW, Qu H, Badell M, Taylor RN, Sidell N. Alternatively Activated Macrophages Are the Primary Retinoic Acid-Producing Cells in Human Decidua. Reprod Sci. 2020 Jan;27(1):334-341. doi: 10.1007/s43032-019-00030-7. Epub 2020 Jan 1. PMID: 32046391; PMCID: PMC7539807.

Huang W, Yu J, Liu T, Defnet AE, Zalesak S, Farese AM, MacVittie TJ, Kane MA. Proteomics of Non-human Primate Plasma after Partial-body Radiation with Minimal Bone Marrow Sparing. Health Phys. 2020 Nov;119(5):621-632. doi: 10.1097/HP.0000000000001350. PMID: 32947488; PMCID: PMC7541796.

Brewer LK, Huang W, Hackert BJ, Kane MA, Oglesby AG. Static Growth Promotes PrrF and 2-Alkyl-4(1H)-Quinolone Regulation of Type VI Secretion Protein Expression in Pseudomonas aeruginosa. J Bacteriol. 2020 Nov 19;202(24):e00416-20. doi: 10.1128/JB.00416-20. PMID: 33020221; PMCID: PMC7685562.

Neu HM, Lee A, Brandis JEP, Patel V, Schneider A, Kane MA, Dalby RN, Michel SLJ. Cigalike electronic nicotine delivery systems e-liquids contain variable levels of metals. Sci Rep. 2020 Jul 17;10(1):11907. doi: 10.1038/s41598-020-67789-7. PMID: 32681061; PMCID: PMC7368082.

Carter CL, Parker GA, Hankey KG, Farese AM, MacVittie TJ, Kane MA. MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation. Sci Rep. 2020 Jul 14;10(1):11559. doi: 10.1038/s41598-020-68508-y. PMID: 32665567; PMCID: PMC7360629.

Li L, Wang H, Jones JW. Sphingolipid metabolism as a marker of hepatotoxicity in drug-induced liver injury. Prostaglandins Other Lipid Mediat. 2020 Dec;151:106484. doi: 10.1016/j.prostaglandins.2020.106484. Epub 2020 Sep 30. PMID: 33007444; PMCID: PMC7669681.

Hu T, Huang W, Li Z, Kane MA, Zhang L, Huang SM, Wang H. Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells. Toxicol Appl Pharmacol. 2020 Sep 1;402:115117. doi: 10.1016/j.taap.2020.115117. Epub 2020 Jul 4. PMID: 32634519; PMCID: PMC7398853.

Huang W, Yu J, Liu T, Tudor G, Defnet AE, Zalesak S, Kumar P, Booth C, Farese AM, MacVittie TJ, Kane MA. Proteomic Evaluation of the Natural History of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Non-human Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing Includes Dysregulation of the Retinoid Pathway. Health Phys. 2020 Nov;119(5):604-620. doi: 10.1097/HP.0000000000001351. PMID: 32947489; PMCID: PMC7541663.

Brewer LK, Huang W, Hackert BJ, Kane MA, Oglesby AG. Static Growth Promotes PrrF and 2-Alkyl-4(1H)-Quinolone Regulation of Type VI Secretion Protein Expression in Pseudomonas aeruginosa. J Bacteriol. 2020 Nov 19;202(24):e00416-20. doi: 10.1128/JB.00416-20. PMID: 33020221; PMCID: PMC7685562.

Tran A, Wan L, Xu Z, Haro JM, Li B, Jones JW. Lithium Hydroxide Hydrolysis Combined with MALDI TOF Mass Spectrometry for Rapid Sphingolipid Detection. J. Am. Soc. Mass Spectrom. 2020 Oct 30; 32, 1, 289–300. https://doi.org/10.1021/jasms.0c00322

Ok K, Li W, Neu HM, Batelu S, Stemmler TL, Kane MA , Michel SLJ. Role of Gold in Inflammation and Tristetraprolin Activity. Chem. Eur. J. 2020, 26, 1535. https://doi.org/10.1002/chem.201904837

Brewer LK, Jones JW, Blackwood CB, Barbier M, Oglesby-Sherrouse A, Kane MA. Development and bioanalytical method validation of an LC-MS/MS assay for simultaneous quantitation of 2-alkyl-4(1H)-quinolones for application in bacterial cell culture and lung tissue. Anal Bioanal Chem 412, 1521–1534 (2020). https://doi.org/10.1007/s00216-019-02374-0

Klontz EH, Li C, Kihn K, Fields JK, Beckett D, Snyder GA, Wintrode PL, Deredge D, Wang LX, Sundberg EJ. Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nat Commun. 2020 Dec 4;11(1):6204. doi: 10.1038/s41467-020-20044-z. PubMed PMID: 33277506; PubMed Central PMCID: PMC7718225

Centola G, Deredge DJ, Hom K, Ai Y, Dent AT, Xue F, Wilks A. Gallium(III)-Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition. ACS Infect Dis. 2020 Aug 14;6(8):2073-2085. doi: 10.1021/acsinfecdis.0c00138. Epub 2020 Jul 6. PMID: 32551497; PMCID: PMC7456513.

Orlandi C, Deredge D, Ray K, Gohain N, Tolbert W, DeVico AL, Wintrode P, Pazgier M, Lewis GK. Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding. Structure. 2020 May 5;28(5):516-527.e5. doi: 10.1016/j.str.2020.03.001. Epub 2020 Mar 24. PMID: 32209433; PMCID: PMC7288244.

Chea EE, Deredge DJ, Jones LM. Insights on the Conformational Ensemble of Cyt C Reveal a Compact State during Peroxidase Activity. Biophys J. 2020 Jan 7;118(1):128-137. doi: 10.1016/j.bpj.2019.11.011. Epub 2019 Nov 20. PMID: 31810655; PMCID: PMC6950772.

Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane IP, Hussain A, Qiu Y, Weber DJ, Njar VCO. Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo. Cancers (Basel). 2019 Oct 24;11(11):1637. doi: 10.3390/cancers11111637. PMID: 31653008; PMCID: PMC6895912.

Wang S, Yu J, Kane MA, Moise AR. Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair. Pharmacol Ther. 2020 Jan;205:107415. doi: 10.1016/j.pharmthera.2019.107415. Epub 2019 Oct 16. PMID: 31629008; PMCID: PMC7299003.

Liu T, Kotha RR, Jones JW, Polli JE, Kane MA. Fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of eight antiepileptic drugs and an active metabolite in human plasma using polarity switching and timed selected reaction monitoring. J Pharm Biomed Anal. 2019 Nov 30;176:112816. doi: 10.1016/j.jpba.2019.112816. Epub 2019 Aug 17. PMID: 31465890.

Li Y, Jones JW, M C Choi H, Sarkar C, Kane MA, Koh EY, Lipinski MM, Wu J. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury. Cell Death Dis. 2019 Jul 11;10(7):531. doi: 10.1038/s41419-019-1764-1. 

Defnet AE, Huang W, Polischak S, Yadav SK, Kane MA, Shapiro P, Deshpande DA. Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation. FASEB J. 2019 Oct;33(10):10833-10843. doi: 10.1096/fj.201900680R. Epub 2019 Jul 26. PMID: 31266368; PMCID: PMC6766654.

Kim D, Chen R, Sheu M, Kim N, Kim S, Islam N, Wier EM, Wang G, Li A, Park A, Son W, Evans B, Yu V, Prizmic VP, Oh E, Wang Z, Yu J, Huang W, Archer NK, Hu Z, Clemetson N, Nelson AM, Chien A, Okoye GA, Miller LS, Ghiaur G, Kang S, Jones JW, Kane MA, Garza LA. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Nat Commun. 2019 Jun 26;10(1):2811. doi: 10.1038/s41467-019-10811-y. PMID: 31243280; PMCID: PMC6594970.

Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 2020 Mar;16(3):466-485. doi: 10.1080/15548627.2019.1628538. Epub 2019 Jun 25. PMID: 31238788; PMCID: PMC6999646.

Nelson CE, Huang W, Brewer LK, Nguyen AT, Kane MA, Wilks A, Oglesby-Sherrouse AG. Proteomic Analysis of the Pseudomonas aeruginosa Iron Starvation Response Reveals PrrF Small Regulatory RNA-Dependent Iron Regulation of Twitching Motility, Amino Acid Metabolism, and Zinc Homeostasis Proteins. J Bacteriol. 2019 May 22;201(12):e00754-18. doi: 10.1128/JB.00754-18. PMID: 30962354; PMCID: PMC6531625.

Deredge D, Wintrode PL, Tulapurkar ME, Nagarsekar A, Zhang Y, Weber DJ, Shapiro P, Hasday JD. A temperature-dependent conformational shift in p38α MAPK substrate-binding region associated with changes in substrate phosphorylation profile. J Biol Chem. 2019 Aug 23;294(34):12624-12637. doi: 10.1074/jbc.RA119.007525. Epub 2019 Jun 18. PMID: 31213525; PMCID: PMC6709627.

Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S. Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb. Anal Chem. 2019 Jun 4;91(11):7336-7345. doi: 10.1021/acs.analchem.9b01100. Epub 2019 May 14. PMID: 31045344; PMCID: PMC6745711.

Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Günther S, Flores J, Wintrode PL, Wang LX, Guerin ME, Sundberg EJ. Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci. 2019 Mar 27;5(3):524-538. doi: 10.1021/acscentsci.8b00917. Epub 2019 Feb 6. PMID: 30937380; PMCID: PMC6439443.

Taraban MB, Deredge DJ, Smith ME, Briggs KT, Li Y, Jiang ZX, Wintrode PL, Yu YB. Monitoring dendrimer conformational transition using 19 F and 1 H2 O NMR. Magn Reson Chem. 2019 Aug;57(10):861-872. doi: 10.1002/mrc.4849. Epub 2019 Mar 8. PMID: 30746779.

Deepak V, Sahu MB, Yu J, Jones JW, Kane MA, Taylor RN, Badell ML, Sidell N, Rajakumar A. Retinoic Acid Is a Negative Regulator of sFLT1 Expression in Decidual Stromal Cells, and Its Levels Are Reduced in Preeclamptic Decidua. Hypertension. 2019 Mar 18:HYPERTENSIONAHA11812564. doi: 10.1161/HYPERTENSIONAHA.118.12564. [Epub ahead of print] PMID:30879360

Ramalingam S, Ramamurthy VP, Gediya LK, Murigi FN, Purushottamachar P, Huang W, Choi EY, Zhang Y, Vasaitis TS, Kane MA, Lapidus RG, Njar VCO. The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis. Cancers (Basel). 2019 Mar 3;11(3). pii: E299. doi: 10.3390/cancers11030299. PMID:30832411

Tomich AD, Klontz EH, Deredge D, Barnard JP, McElheny CL, Eshbach ML, Weisz OA, Wintrode P, Doi Y, Sundberg EJ, Sluis-Cremer N. Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01524-18. doi: 10.1128/AAC.01524-18. PMID: 30642934; PMCID: PMC6395921.

Jones JW, Sarkar C, Lipinski MM, Kane MA. Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC-HDMS_E. Proteomics. 2019 Feb 20:e1800297. doi: 10.1002/pmic.201800297. [Epub ahead of print] PMID:30790445

MacVittie TJ, Farese AM, Kane MA. ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome. Health Phys. 2019 Apr;116(4):453. doi: 10.1097/HP.0000000000001050. No abstract available.  PMID:30789495

Saha Ray A, Ghann WE, Tsoi PS, Szychowski B, Dockery LT, Pak YJ, Li W, Kane MA, Swaan P, Daniel MC. Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form. Langmuir. 2019 Mar 5;35(9):3391-3403. doi: 10.1021/acs.langmuir.8b03196. Epub 2019 Feb 18. PMID:30712354

Jones JW, Alloush J, Sellamuthu R, Chua HL, MacVittie TJ, Orschell CM, Kane MA. Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome. Health Phys. 2019 Apr;116(4):484-502. doi: 10.1097/HP.0000000000000961. PMID:30681425

Carter CL, Hankey KG, Booth C, Tudor GL, Parker GA, Jones JW, Farese AM, MacVittie TJ, Kane MA. Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI. Health Phys. 2019 Apr;116(4):454-472. doi: 10.1097/HP.0000000000000948. PMID:30681424

Neu HM, Alexishin SA, Brandis JEP, Williams AMC, Li W, Sun D, Zheng N, Jiang W, Zimrin A, Fink JC, Polli JE, Kane MA, Michel SLJ. Snapshots of Iron Speciation: Tracking the Fate of Iron Nanoparticle Drugs via a Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Approach. Mol Pharm. 2019 Mar 4;16(3):1272-1281. doi: 10.1021/acs.molpharmaceut.8b01215. Epub 2019 Feb 14. PMID:30676753

Huang W, Yu J, Jones JW, Carter CL, Jackson IL, Vujaskovic Z, MacVittie TJ, Kane MA. Acute Proteomic Changes in the Lung After WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure. Health Phys. 2019 Apr;116(4):503-515. doi: 10.1097/HP.0000000000000956. PMID:30652977

Huang W, Yu J, Jones JW, Carter CL, Pierzchalski K, Tudor G, Booth C, MacVittie TJ, Kane MA. Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model. Health Phys. 2019 Apr;116(4):516-528. doi: 10.1097/HP.0000000000000951. PMID:30624357

Jones JW, Clifford Z, Li F, Tudor GL, Farese AM, Booth C, MacVittie TJ, Kane MA. Targeted Metabolomics Reveals Metabolomic Signatures Correlating Gastrointestinal Tissue to Plasma in a Mouse Total-body Irradiation Model. Health Phys. 2019 Apr;116(4):473-483. doi: 10.1097/HP.0000000000000955.PMID:30624349

MacVittie TJ, Farese AM, Kane MA. ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome. Health Phys. 2019 Mar;116(3):297-304. doi: 10.1097/HP.0000000000001045. No abstract available. PMID:30608246

Cohen EP, Hankey KG, Farese AM, Parker GA, Jones JW, Kane MA, Bennett A, MacVittie TJ. Radiation Nephropathy in a Nonhuman Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing-Part 1: Acute and Chronic Kidney Injury and the Influence of Neupogen. Health Phys. 2019 Mar;116(3):401-408. doi: 10.1097/HP.0000000000000960. PMID:30608245

Bakhireva LN, Kane MA, Bearer CF, Bautista A, Jones JW, Garrison L, Begay MG, Ozechowski T, Lewis J. Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest. Birth Defects Res. 2019 Jan 15;111(2):53-61. doi: 10.1002/bdr2.1427. Epub 2018 Dec 14. PMID:30549447

Teletin M, Vernet N, Yu J, Klopfenstein M, Jones JW, Féret B, Kane MA, Ghyselinck NB, Mark M. Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium. Development. 2019 Jan 4;146(1). pii: dev170225. doi: 10.1242/dev.170225. PMID:30487180

Perri M, Yap JL, Fletcher S, Cione E, Kane MA. Therapeutic potential of Bcl-x_L/Mcl-1 synthetic inhibitor JY-1-106 and retinoids for human triple-negative breast cancer treatment. Oncol Lett. 2018 May;15(5):7231-7236. doi: 10.3892/ol.2018.8258. Epub 2018 Mar 14. PMID:29849791

Wang S, Huang W, Castillo HA, Kane MA, Xavier-Neto J, Trainor PA, Moise AR. Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature. Dev Dyn. 2018 Aug;247(8):976-991. doi: 10.1002/dvdy.24639. PMID:29806219

Bonsor DA, Zhao Q, Schmidinger B, Weiss E, Wang J, Deredge D, Beadenkopf R, Dow B, Fischer W, Beckett D, Wintrode PL, Haas R, Sundberg EJ. The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J. 2018 Jul 2;37(13):e98664. doi: 10.15252/embj.201798664. Epub 2018 May 3. PMID: 29724755; PMCID: PMC6028028.

Makar T, Nimmagadda VK, Guda PR, Hampton B, Huang W, Kane MA, Fishman PS, Pessac B, Bever CT Jr., Trisler D. A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions. Stem Cell Res Ther. 2018 May 2;9(1):127. doi: 10.1186/s13287-018-0858-5. PMID: 29720239

Djapgne L, Panja S, Brewer LK, Gans JH, Kane MA, Woodson SA, Oglesby-Sherrouse AG. The Pseudomonas aeruginosa PrrF1 and PrrF2 Small Regulatory RNAs Promote 2-Alkyl-4-Quinolone Production through Redundant Regulation of the antR mRNA. J Bacteriol. 2018 Apr 24;200(10). pii: e00704-17. doi: 10.1128/JB.00704-17. Print 2018 May 15. PMID: 29507088

Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation. Sci Adv. 2018 Feb 21;4(2):eaao1261. doi: 10.1126/sciadv.aao1261. eCollection 2018 Feb. PMID: 29492455

Wang S, Yu J, Jones JW, Pierzchalski K, Kane MA, Trainor PA, Xavier-Neto J, Moise AR. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells. FASEB J. 2018 Feb 15:fj201701038R. doi: 10.1096/fj.201701038R. [Epub ahead of print] PMID: 29447006

Lo PK, Yao Y, Lee JS, Zhang Y, Huang W, Kane MA, Zhou Q. LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer. Elife. 2018 Jan 19;7. pii: e31334. doi: 10.7554/eLife.31334. PMID: 29350614

Collier AF, Gumerson J, Lehtimäki K, Puoliväli J, Jones JW, Kane MA, Manne S, O'Neill A, Windish HP, Ahtoniemi T, Williams BA, Albrecht DE, Bloch RJ. Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice. J Pharmacol Exp Ther. 2018 Mar;364(3):409-419. doi: 10.1124/jpet.117.244244. Epub 2017 Dec 28. PMID: 29284661

McCarty DJ, Huang W, Kane MA, Purushottamachar P, Gediya LK, Njar VCO. Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model. Oncotarget. 2017 Aug 1;8(51):88501-88516. doi: 10.18632/oncotarget.19762. eCollection 2017 Oct 24. PMID: 29179452

Huang W, Brewer LK, Jones JW, Nguyen AT, Marcu A, Wishart DS, Oglesby-Sherrouse AG, Kane MA, Wilks A. PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database. Nucleic Acids Res. 2018 Jan 4;46(D1):D575-D580. doi: 10.1093/nar/gkx1061. PMID: 29106626

Thom SR, Bhopale VM, Yu K, Huang W, Kane MA, Margolis DJ. Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability. J Biol Chem. 2017 Nov 3;292(44):18312-18324. doi: 10.1074/jbc.M117.802629. Epub 2017 Sep 25. PMID: 28972154

Jones JW, Jackson IL, Vujaskovic Z, Kaytor MD, Kane MA. Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury. Pharm Res. 2017 Dec;34(12):2698-2709. doi: 10.1007/s11095-017-2200-9. Epub 2017 Oct 2. PMID: 28971289

Carter CL, Jones JW, Farese AM, MacVittie TJ, Kane MA. Lipidomic dysregulation within the lung parenchyma following whole-thorax lung irradiation: Markers of injury, inflammation and fibrosis detected by MALDI-MSI. Sci Rep. 2017 Sep 4;7(1):10343. doi: 10.1038/s41598-017-10396-w. PMID: 28871103

Mackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H. Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor. Mol Pharmacol. 2017 Jul;92(1):75-87. doi: 10.1124/mol.117.108621. Epub 2017 Apr 25. PMID: 28442602

Reinhart AA, Nguyen AT, Brewer LK, Bevere J, Jones JW, Kane MA, Damron FH, Barbier M, Oglesby-Sherrouse AG. The Pseudomonas aeruginosa PrrF Small RNAs Regulate Iron Homeostasis during Acute Murine Lung Infection. Infect Immun. 2017 Apr 21;85(5). pii: e00764-16. doi: 10.1128/IAI.00764-16. Print 2017 May. PMID: 28289146

Li X, Cox JT, Huang W, Kane M, Tang K, Bieberich CJ. Quantifying Kinase-Specific Phosphorylation Stoichiometry Using Stable Isotope Labeling In a Reverse In-Gel Kinase Assay. Anal Chem. 2016 Dec 6;88(23):11468-11475. Epub 2016 Nov 18. PMID: 27808495

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy. Science. 2016 Oct 14;354(6309):197-202. PMID: 27738167

Li W, Yu J, Kane MA. Quantitation of the Noncovalent Cellular Retinol-Binding Protein, Type 1 Complex Through Native Mass Spectrometry. J Am Soc Mass Spectrom. 2017 Jan;28(1):29-37. doi: 10.1007/s13361-016-1499-5. Epub 2016 Oct 5. PMID: 27709511

Jones JW, Carter CL, Li F, Yu J, Pierzchalski K, Jackson IL, Vujaskovic Z, Kane MA. Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification. Biomed Chromatogr. 2017 Mar;31(3). doi: 10.1002/bmc.3822. Epub 2016 Sep 29. PMID: 27557409

Klontz, E., Tomich, A., Gunther, S., Lemkul, J., Deredge, D., Silverstein, Z., Shaw, J., McElheny, C., Doi, Y., Wintrode, P.L., MacKerell, A., Sluis-Cremer, N. and Sundberg, E. (2017) Structure and dynamics of FosA-mediated fosfomycin resistance in Klebsiella pneumoniae and Escherichia coli. Antimicrob. Agents Chemother. in press.

Günther, S., Deredge, D., Bowers, A.L., Luchini, A., Bonsor, Beadenkopf, R., Liotta, L., Wintrode, P.L. and Sundberg, E.J. (2017) Molecular Basis of Receptor Sharing in the IL-1 Family. Immunity 47, 510-523.

Deredge, D.J.*, Huang, W., Hui, C., Matsumura, H., Yue, Z., Moenne-Loccoz, P., Shen, J., Wintrode, P.L. and Wilks, A. (2017) Ligand Induced Allostery in the Interaction of the Pseudomonas aeruginosa Heme Binding Protein (PhuS) with Heme Oxygenase (HemO). Proc. Natl. Acad. Sci. USA 114 3421-3426.

Malik, R., Dau, T., Gonik, M., Sivakumar*, A., Deredge, D.J.*, Edeleva, E.E., Götzfried, J., van der Laan, S.W., Pasterkamp, G., Beaufort, N., Seixas, S., Bevan, S., Lincz, L.F., Holliday, E.G., Burgess, A.I., Rannikmae, K., Minnerup, J., Kriebel, J., Waldenberger, M., Müller-Nurasyid, M., Lichtner, P., Saleheen, D., International Stroke Genetics Consortium, Rothwell, P.M., Levi, C., Attia, J., Sudlow, C.M., Braun, D., Markus, H.S., Wintrode, P.L., Berger, K., Jenne, D.E. and Dichgans, M. (2017) A Common Coding Variant in SERPINA1 Increases the Risk for Large Artery Stroke. Proc. Natl. Acad. Sci. USA 114 3613-3618.

Adhikary, A., Deredge, D.*, Nagarajan, A., Forrest, L.R., Wintrode, P.L. and Singh, S.K. (2017) Conformational dynamics of a neurotransmitter sodium symporter in a lipid bilayer. Proc. Natl. Acad. Sci. USA 114 1786-1795.

Postel, S., Deredge, D.*, Bonsor, D.A., Yu, X., Diederichs, K., Helmsing, S., Vromen, A., Friedler, A., Hust, M., Egelman, E.H., Beckett, D., Wintrode, P.L. and Sundberg, E.J. (2016) Bacterial Flagellar Capping Proteins Adopt Diverse Oligomeric States. eLife, 10.7554/eLife.18857.

Tsutsui, Y. Deredge, D.,* Wintrode, P.L. and Hayes, F.A. (2016) Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel 2 kinase inhibition strategy. Sci. Rep. 6, 30832.

Nguyen AT, Jones JW, Cámara M, Williams P, Kane MA, Oglesby-Sherrouse AG. Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones. Front Microbiol. 2016 Jul 27;7:1171. doi: 10.3389/fmicb.2016.01171. eCollection 2016. PMID: 27512392

Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA. Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016 Jul 15;17(1):49. doi: 10.1186/s12868-016-0284-5. PMID: 27422020

Bansal N, Bosch A, Leibovitch B, Pereira L, Cubedo E, Yu J, Pierzchalski K, Jones JW, Fishel M, Kane M, Zelent A, Waxman S, Farias E. Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer. Oncotarget. 2016 Jul 12;7(28):43689-43702. doi: 10.18632/oncotarget.9905. PMID: 27286261

Carter CL, Jones JW, Farese AM, MacVittie TJ, Kane MA. Inflation-Fixation Method for Lipidomic Mapping of Lung Biopsies by Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging. Anal Chem. 2016 May 3;88(9):4788-94. doi: 10.1021/acs.analchem.6b00165. Epub 2016 Apr 19. PMID: 27028398

Futrega K, Yu J, Jones JW, Kane MA, Lott WB, Atkinson K, Doran MR. Polydimethylsiloxane (PDMS) modulates CD38 expression, absorbs retinoic acid and may perturb retinoid signalling. Lab Chip. 2016 Apr 21;16(8):1473-83. doi: 10.1039/c6lc00269b. PMID: 27008339

Williams CL, Neu HM, Gilbreath JJ, Michel SL, Aurawski DV, Merrell DS. Characterization of Copper Resistance in Acinetobacter bauminnii. Appl Environ Microbiol. 2016 Aug 12. pii: AEM.01813-16. PMID: 27520808

Deredge D, Li J, Johnson KA, Wintrode PL. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase. J Biol Chem. 2016 Mar 22. pii: jbc.M115.708370. PMID: 27006396

Alonso S, Su M, Jones JW, Ganguly S, Kane MA, Jones RJ, Ghiaur G. Human Bone Marrow Niche Chemoprotection Mediated by Cytochrome P450 Enzymes. Oncotarget. 2015 Jun 20;6(17):14905-12. PMID: 25915157. PMCID: PMC4558124

Best MW, Wu J, Pauli SA, Kane MA, Pierzchalski K, Session DR, Woods DC, Shang W, Taylor RN, Sidell N. A role for retinoids in human oocyte fertilization: Regulation of connexin 43 by retinoic acid in cumulus granulosa cells. Mol Hum Reprod. 2015 Jun;21(6):527-34. doi: 10.1093/molehr/gav017. Epub 2015 Apr 15. PMID: 25877907

Byrareddy SN, Sidell N, Zhao C, Dunbar P, Little D, Yang GX, Pierzchalski K, Kane MA, Mayne A, Arthos J, Cicala C, Song B, Soares MA, Villinger F, Ansari A. Species-Specific Differences in the Expression and Regulation of Alpha 4 Beta7 (α4β7) integrin in Various Non-Human Primates. Journal of Immunology. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6. PMID: 25948815

Carter CL, Jones JW, Barrow K, Kieta K, Taylor-Howell C, Kearney S, Smith CP, Gibbs A, Farese AM, MacVittie TJ, Kane MA. A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development. Health Phys. 2015 Nov;109(5):466-78. doi: 10.1097/HP.0000000000000353. PMID: 26425906

Jones JW, Bennett A, Carter CL, Tudor G, Hankey KG, Farese AM, Booth C, MacVittie TJ, Kane MA. Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury. Health Phys. 2015 Nov;109(5):440-51. doi: 10.1097/HP.0000000000000347. PMID: 26425904

Jones JW, Pierzchalski K, Yu J, Kane MA. The use of fast HPLC multiplexing MRM³ for endogenous retinoic acid quantification in complex matrices. Anal Chem. 2015 Mar 17;87(6):3222-30. doi: 10.1021/ac504597q. Epub 2015 Mar 9. PMID: 25704261

Jones JW, Thompson CJ, Carter CL, Kane MA. Electron-induced dissociation (EID) for structure characterization of glycerophosphatidylcholine: determination of double-bond positions and localization of acyl chains. J Mass Spectrom. 2015 Dec;50(12):ii. doi: 10.1002/jms.3499. PMID: 26634981

Jones JW, Tudor G, Li F, Tong Y, Katz B, Farese AM, MacVittie TJ, Booth C, Kane MA. Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology. Health Phys. 2015 Nov;109(5):452-65. doi: 10.1097/HP.0000000000000346. PMID: 26425905

Lupton, C.J., Steer, D.L., Wintrode, P.L., Bottomley, S.P., Hughes, V.A. and Ellison, A.M. (2015) Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease. J. Biol. Chem., 290 24190-24200. DOI:10.1074/jbc.M115.659532. PMID: 26260925

Nguyen AT, Jones JW, Ruge MA, Kane MA, Oglesby-Sherrouse AG Iron Depletion Enhances Production of Antimicrobials by Pseudomonas aeruginosa. J Bacteriol. 2015 Jul;197(14):2265-75. doi: 10.1128/JB.00072-15. Epub 2015 Apr 27. PMID: 25917911. PMCID: PMC4524187

Reinhart AA, Powell DA, Nguyen AT, O’Neill M, Djapgne L, Wilks A, Ernst RK, Oglesby-Sherrouse AG. (2015) The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infection and Immunity 83(3):863-875. PMID: 25510881

Su M, Alonso-Martinez S, Jones JW, Yu J, Kane MA, Jones RJ, Ghiaur G. All-Trans Retinoic Acid Activity in Human Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment. PLoS One. 2015 Jun 5;10(6):e0127790. doi: 10.1371/journal.pone.0127790. eCollection 2015. PMID: 26047326. PMCID: PMC4457893

Taylor RN, Kane MA, Sidell N. Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways. Semin Reprod Med. 2015 Jul;33(4):246-56. doi: 10.1055/s-0035-1554920. Epub 2015 Jul 1. PMID: 26132929

Ting TY, Jiang W, Lionberger R, Wong J, Jones JW, Kane MA, Krumholz A, Temple R, Polli JE. Generic lamotrigine versus brand-name Lamictal bioequivalence in patients with epilepsy: A field test of the FDA bioequivalence standard. Epilepsia. 2015 Sep;56(9):1415-24. doi: 10.1111/epi.13095. Epub 2015 Jul 23. PMID: 26201987

Vaithianathan S, Haidar SH, Zhang X, Jiang W, Avon C, Dowling TC, Shao C, Kane M, Hoag SW, Flasar MH, Ting TY, Polli JE. Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir. J Pharm Sci. 2015 Sep 16. doi: 10.1002/jps.24643. PMID: 26375604

Vaithianathan S, Raman S, Jiang W, Ting TY, Kane MA, Polli JE. Biopharmaceutic Risk Assessment of Brand and Generic Lamotrigine Tablets. Mol Pharm. 2015 Jul 6;12(7):2436-43. doi: 10.1021/acs.molpharmaceut.5b00154. Epub 2015 Jun 2. PMID: 26001027

Wehman B, Dawood M, Ghoreishi M, Cheema F, Jones JW, Kane MA, Ward CW, Gammie JS. Surgical Management of Caseous Calcification of the Mitral Annulus. Ann Thorac Surg. 2015 Jun;99(6):2231-3. doi: 10.1016/j.athoracsur.2015.02.106. PMID: 26046892

White, M., Khan, M.M., Deredge, D., Ross, C.R., Quintyn, R., Zucconi, B.E., Wysocki, V.H., Wintrode, P.L., Wilson, G.M. and Garcin, E.D. (2015) A dimer interface mutation in glyceraldehyde-3-phosphate dehydrogenase regulates its binding to AU-rich RNA. J. Biol. Chem., 290 1770-1785. DOI:10.1074/jbc.M114.618165. PMID: 25681510

Carter CL, MacVittie TJ, Kane MA. MALDI-MSI: Biomarker Discovery for Radiation Exposures. Three Encyclopedia, Systems Biology, 2014 (March 24).

Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Pierzchalski K, Jones JW, Kane M, Nishikawa JI, Hiromori Y, Nakanishi T, Santos MM, Castro LF, Bourguet W, Schubert M, Laudet V. A mollusk Retinoic Acid Receptor (RAR) ortholog sheds light on the evolution of ligand binding. Endocrinology. 2014 Aug 13:en20141181. [Epub ahead of print]. PMID: 25116705. PMCID: PMC4197984

Hughes, V.A., Meklemburg, R., Bottomley, S.P. and Wintrode P.L. (2014) The Z mutation alters the global structural dynamics of alpha-1 antitrypsin. PLoS ONE 9(9):e102617. doi:10.1371/journal.pone.0102617. PMID: 25181470

Jones JW, Scott AJ, Tudor G, Xu PT, Jackson IL, Vujaskovic Z, Booth C, MacVittie TJ, Ernst RK, Kane MA. Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry. Health Phys. 2014 Jan;106(1):106-19. doi: 10.1097/HP.0b013e3182a4ed3b. PMID: 24276554. PMCID: PMC3843144

Jones JW, Tudor G, Bennett A, Farese AM, Moroni M, Booth C, MacVittie TJ, Kane MA. Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species. Anal Bioanal Chem. 2014 Jul;406(19):4663-75. doi: 10.1007/s00216-014-7870-0. Epub 2014 May 20. PMID: 24842404

Osborne J, Djapgne L, Tran B, Goo YA, Oglesby-Sherrouse AG. (2014) A method for in vivo identification of bacterial small RNA binding proteins. Microbiology Open 3(6):950-60. PMID: 25351924

Perri M, Yap JL, Yu J, Cione E, Fletcher S, Kane MA. BCL-x_L/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells. Exp Cell Res. 2014 Oct 1;327(2):183-91. doi: 10.1016/j.yexcr.2014.07.024. Epub 2014 Aug 1. PMID: 25088254

Pierzchalski K, Taylor RN, Nezhat C, Jones JW, Napoli JL, Yang G, Kane MA, Sidell N. Retinoic Acid Biosynthesis Is Impaired in Human and Murine Endometriosis. Biol Reprod. 2014 2014 Oct;91(4):84. doi: 10.1095/biolreprod.114.119677. Epub 2014 Aug 20. (+ Kane & Sidell are equal co-corresponding authors). PMID: 25143356. PMCID: PMC4435029

Scott AJ, Jones JW, Orschell CM, MacVittie TJ, Kane MA, Ernst RK. Mass spectrometry imaging enriches biomarker discovery approaches with candidate mapping. Health Phys. 2014 Jan;106(1):120-8. doi: 10.1097/HP.0b013e3182a4ec2f. PMID: 24276555. PMCID: PMC4015108

Snyder, G.A., Deredge, D.*, Waldhuber, A., Fresquez, T., Wilkins, D.Z., Smith, P., Durr, S., Cirl, C., Jian, J., Jennings, W., Luchetti, T., Snyder, N., Sundberg, E.J., Wintrode, P.L., Miethke, T. and Xiao, T.S. (2014) Crystal structures of the TIR domains from the Brucella protein TcpB and the host adaptor protein TIRAP reveal mechanisms of molecular mimicry. J. Biol. Chem. 289 669-679. DOI: 10.1074/jbc.M113.523407. PMID: 24275656

Tang N, Bamford P, Jones J, He M, Kane MA, Mooney SM, Bearer CF. Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. Alcohol Clin Exp Res. 2014 Nov;38(11):2722-30. doi: 10.1111/acer.12554. PMID: 25421509. PMCID: PMC4244605

Wong JM, Jones JW, Jiang W, Polli JE, Kane MA. Quantification of lamotrigine in patient plasma utilizing a fast liquid chromatography-tandem mass spectrometry method with backflush technology. Ther Drug Monit. 2015 Apr;37(2):188-97. doi:10.1097/FTD.0000000000000123. PMID: 25162213

Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89. doi: 10.1096/fj.13-227967. Epub 2013 Sep 4. PMID: 24005908. PMCID: PMC3834788

Healy JR, Bezawada P, Shim J, Jones JW, Kane MA, MacKerell AD Jr, Coop A, Matsumoto RR. Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities. ACS Chem Neurosci. 2013 Sep 18;4(9):1256-66. doi: 10.1021/cn4000428. Epub 2013 Jun 11. PMID: 23713721. PMCID: PMC3778426

Pauli SA, Session DR, Shang W, Easley K, Wieser F, Taylor RN, Pierzchalski K, Napoli JL, Kane MA, Sidell N. Analysis of follicular fluid retinoids in women undergoing in vitro fertilization: retinoic acid influences embryo quality and is reduced in women with endometriosis. Reprod Sci. 2013 Sep;20(9):1116-24. doi: 10.1177/1933719113477487. Epub 2013 Feb 20. PMID: 23427183. PMCID: PMC3745715

Pierzchalski K, Yu J, Norman V, Kane MA. CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment. FASEB J. 2013 May;27(5):1904-16. doi: 10.1096/fj.12-219410. Epub 2013 Jan 29. PMID: 23362116

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV. Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5. Oncotarget. 2013 Jun;4(6):936-47. Online ISSN 1949-2553. PMID: 23801058. PMCID: PMC3757250

Cheng, I., Nikita, N., Fishovitz, J., Frase, H., Wintrode, P.L. and Lee, I. (2012) Identification of a region in the N-terminus of escherichia coli lon that affects ATPase, substrate translocation and proteolytic activity. J. Mol. Biol. 418 208-225. DOI: 10.1016/j.jmb.2012.02.039. PMID: 22387465

Kane MA. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim Biophys Acta. 2012 Jan;1821(1):10-20. doi: 10.1016/j.bbalip.2011.09.012. Epub 2011 Oct 1. Review. PMID: 21983272

Shao C, Dowling TC, Haidar S, Yu LX, Polli JE, Kane MA. Quantification of acyclovir in human plasma by ultra-performance liquid chromatography – heated electrospray ionization – tandem mass spectrometry for bioequivalence evaluation. J Anal Bioanal Techniques 2012, 3:4. doi: 10.4172/2155-9872.1000139.

Raufman JP, Xu S, Cheng K, Khurana S, Johnson D, Shao C, Kane MA, Shi D, Gullapalli R, Polli J. In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice. Drug Metab Dispos. 2011 May;39(5):736-9. doi: 10.1124/dmd.110.037358. Epub 2011 Jan 26. PMID: 21270105. PMCID: PMC3082377

Experimental Biology (Orlando, FL) – April 2019

• Amy Defnet¹, Weiliang Huang¹, Maureen Kane¹, Deepak A Deshpande² and Paul Shapiro¹ Comparisons of ATP-competitive (Type I) versus function-selective (Type IV) ERK Inhibitors to Prevent Airway Smooth Muscle Cell Proliferation. Experimental Biology (Orlando, FL) – April 2019. (poster presentation)

11^th Annual Mass Spectrometry: Applications to the Clinical Lab (MSACL) (Palm Springs, CA) – April 2019

• Dominique Figueroa, Maureen A. Kane. MALDI-MSI investigation of lipid alterations in developing rat cerebellum following hypoxic/ischemic insult. 11^th Annual Mass Spectrometry: Applications to the Clinical Lab (MSACL) (Palm Springs, CA) – April 2019 (poster presentation)
• Dominique B. Figueroa¹, Maureen A. Kane. Low extraction efficiency in liquid-liquid extraction and quantification of nicotine, opioids and cannabinoids from plasma, brain, and placental tissue. 11^th Annual Mass Spectrometry: Applications to the Clinical Lab (MSACL) (Palm Springs, CA) – April 2019 (Troubleshooting poster presentation)

Keystone Meeting on Allergic Disease (Lake Tahoe, CA) – March 2019

• Amy Defnet¹, Weiliang Huang¹, Jianshi Yu¹, Jace W. Jones¹, Deepak A. Deshpande², Paul Shapiro¹, Maureen A. Kane¹ Function Selective ERK Inhibition and Restoration of Retinoic Acid as a Therapeutic Approach to Prevent Airway Smooth Muscle Cell Proliferation in Allergic Asthma. Keystone Meeting on Allergic Disease (Lake Tahoe, CA) – March 2019.

NIAID, BARDA, FDA: A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury – March 2019.

• Kane MA. Biomarkers of Radiation-Induced Lung Injury in Animal Models: Diagnostic, Predictive, and Pharmacodynamic Biomarkers. NIAID, BARDA, FDA: A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury. March 2019. (Invited oral presentation)

American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018

• D. Figueroa, M.A. Kane. Toward small volume quantification of vancomycin in pediatric serum using a rapid UPLC-MS/MS method for application in pharmacokinetic studies. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)
• Wenjing Li, Kiwon Ok, Sarah L. J. Michel, Maureen A. Kane. “Gold finger” protein complexes characterized through native mass spectrometry. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)
• C. L. Carter, K. Hankey, G. W. Parker, A. M. Farese, T. J. MacVittie, and M. A. Kane. MALDI-MSI investigation into N-linked glycan alterations following radiation-induce lung injury: Correlations to inflammation and fibrosis. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)
• J. W. Jones, J.Yu S. Wang, A. Moise and M. A. Kane. Stable isotope labeling for tracing retinoid metabolite fate using quantitative mass spectrometry. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)
• R. R. Kotha, J. W. Jones, J. E. Polli, M. A. Kane. Fast liquid chromatography-tandem mass spectrometry for simultaneous determination of antiepileptic drugs using polarity switching and timed selected reaction monitoring. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)
• W. Huang, Z. Li, H. Wang, M. A. Kane. Thermal proteome profiling to identify novel drug targets and mechanisms of phenobarbital in human primary hepatocytes. American Society of Mass Spectrometry Annual Meeting (San Diego, CA) June 2018. (poster presentation)

FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) — June 2018.

• M. A. Kane. Retinoid homeostasis and the tissue microenvironment. FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) June 2018. (oral presentation)
• W. Li, J. Yu, M. A. Kane. Targeted Proteomics Analysis of CrbpI Enables Interrogation of Retinoid Homeostasis and Reveals Potential Diagnostic Value for Cancer. FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) June 2018. (poster and short oral presentation)
• J. Yu, W. Huang, S. Wang, A. R. Moise, M. A. Kane. Systems biology of retinoid-mediated cardiac development. FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) June 2018. (poster and short oral presentation)
• J. Miao, H. Liu, Q. Chen, C. Li, K. Wan, J. Zhang, H. Liu, T. Yang, L. Zou, J. Chen, T. Yu Li. Simultaneous quantification of retinol,retinyl acetate,retinyl palmitate and ß-carotene in dried blood spots using high performance liquid chromatography tandem mass spectrometry. FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) June 2018. (poster presentation)
• A. Defnet, W. Huang, J. Yu, J. W. Jones, D. A. Deshpande, P. Shapiro, M. A. Kane. Involvement of retinoid signaling in airway smooth muscle cell proliferation and tissue remodeling in asthma. FASEB Science Research Conference: The 4^th International Conference on Retinoids (Steamboat Springs, CO) June 2018. (poster presentation)

2017 AAPS Annual Meeting and Exposition (San Diego, CA) — November 2017

• Yu M, Thomas S, Hammell DC, Hassan HE, Stinchcomb AL. A fully validated LC-MS/MS method for simultaneous determination of oxybutynin and its metabolite N-desethyloxybutynin in human serum. Poster presentation at the 2017 AAPS Annual Meeting and Exposition; November 12-15, 2017; San Diego, CA
• Shin S, Yu M, Thomas S, Hammell DC, Ghosh P, Raney SG, Hassan HE, Stinchcomb AL. Level A in vitro/in vivo correlations for nicotine and fentanyl transdermal delivery systems with a transient heat exposure, evaluated by multiple approaches. Poster presentation at the 2017 AAPS Annual Meeting and Exposition; November 12-15, 2017; San Diego, CA

Gordon Conference (Waterville Valley, NH) — August 2017

• Shin S, Yu M, Thomas S, Hammell DC, Ghosh P, Raney SG, Hassan HE, Stinchcomb AL. Level A in vitro/in vivo correlations for nicotine and fentanyl transdermal delivery systems with a transient heat exposure, evaluated by multiple approaches. Poster presentation at the 2017 Gordon Conference “Barrier Function of Mammalian Skin”; August 13-18, 2017; Waterville Valley, NH

18^th International Symposium on Carotenoids (Lucerne, Switzerland) — July 2017

• Jianshi Yu, Jace W. Jones, Keely Pierzchalski, Wenjing Li, Jenna Alloush, Maureen A. Kane. The role of CRBPI in retinoid homeostasis. 18^th International Symposium on Carotenoids (Lucerne, Switzerland) July 2017. (oral presentation)

American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) — June 2017

• W. Li, J. Yu, N. Sidell, M. A Kane. Targeted proteomics of key regulators of all-trans retinoic acid during SIV infection. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• J. W. Jones, M. D. Kaytor, R. Pavlovic, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 in the Whole Thorax Lung Irradiation Mouse Model. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• X. Li, W. Huang, M. A. Kane, C. J. Bieberich. Identification of physiological kinase substrates from cell extracts by differential phosphorylation using reverse in-gel kinase assay and nano-LC tandem MS. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• J. W. Jones, C. Sarkar, M. M. Lipinski, and M. A. Kane. Identification of Ether Glycerophosphoethanolamine from Brain Lysosomes.American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• J. Alloush, J. W. Jones, C. L. Carter, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Metabolomic interrogation of the mechanisms of radiation-induced lung injury. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• J. A. Espino, C. L. Carter, M. A. Kane, L. M. Jones. Using MALDI-Mass Spectrometry Imaging to Assess the Oxidative Damage to Lipids Induced by In Vivo Hydroxyl Radical-Based Protein Footprinting. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)
• C. L. Carter; K. Hankey; J. W. Jones; A. M. Farese; T. J. MacVittie; M. A. Kane. MALDI-MSI Characterization of the Mesenteric Lymph Nodes during the Development of Pathophysiological Processes: An Acute Radiation Injury Model. American Society of Mass Spectrometry Annual Meeting (Indianapolis, IN) June 2017. (poster presentation)

BioMET Annual Retreat (Baltimore, MD) — April 2017

• M.A. Kane. Empowering Biological Discovery and Drug Development with Mass Spectrometry-Based Tools. BioMET Annual Retreat (Baltimore, MD) April 2017. (oral presentation)

U.S. HUPO Conference (Boston, MA) — March 2016

• N. Yang¹; T. Liu¹; B. O'Rourke¹; M. Kane²; D. B. Foster¹. Quantitative Proteomics & Network Analysis Identifies Retinoic Acid Therapy to Bypass Impaired Vitamin A Metabolism in Heart Failure. US HUPO 2016 Conference (Boston, MA). March 2016. (poster presentation)

AAPS Annual Meeting and Exposition (Denver, CO) — November 2016

• Yu M, Shin S, Hammell DC, Hassan HE, Stinchcomb AL. Pharmacokinetics of fentanyl after using reference and generic transdermal fentanyl patches with and without standardized heat application in healthy human volunteers. Poster presentation at the 2016 AAPS Annual Meeting and Exposition; November 13-17, 2016; Denver, CO
Shin S, Yu M, Quarterman JC, Hammell DC, Hassan HE, Stinchcomb AL. In vitro and in vivo evaluation of three fentanyl transdermal delivery systems in conjunction with transient heat exposure. Poster presentation at the 2016 AAPS Annual Meeting and Exposition; November 13-17, 2016; Denver, CO

Waters Seminar - Using HDX MS to Characterize Biomolecules (Baltimore, MD) — June 2016.

• D. Deredge. Insights from HDX_MS into the Drug DIscovery and Development Process. Waters Seminar - Using HDX MS to Characterize Biomolecules (Baltimore, MD) June 2016. (oral presentation)

American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) — June 2016

• W. Li, J. Yu, C. L. Carter, J. W. Jones, M. A. Kane. Targeted Quantitation of CrbpI in Cancer Cells through a Bottom-Up Approach. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (poster presentation)
• C. L. Carter, J. W. Jones, K. Hankey, A. M. Farese, T. J. MacVittie, M. A. Kane. Characterizing the Natural History of Acute Radiation Syndrome of the Castrointestinal Tract: Combining High Mas and Spatial Resolution using MALDI-FTICR-MSI. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation)
• J. W. Jones, C. L. Carter, M. A. Kane. Electron-Induced Dissociation (EID) of Lipids: Diagnostic Product Ions for Confident Identification of Isomers. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation)
• M. A. Kane, L. Brewer, B. Giardina, J. W. Jones, A. Nguyen, A. Oglesby-Sherrouse, A. Wilks. Discovery and Quantitative Metabolomics to Characterize Metabolites of Bacterial Origin as Biomarkers for Cystic Fibrosis. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation)

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD) — January 2016

• P. Wintrode. Hydrogen/Deuterium Exchange (HDX) in conjunction with mass spectrometry to learn how dynamics mediate the function and inhibition of proteins. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). January 2016 Meeting (oral presentation).

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD) — November and June 2015

• S. Michel. ICP-MS to the Rescue: Counting Metal Ions in Metalloproteins, Tissues and Plasma. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). November 2015 Meeting (oral presentation).
• W. Li; B. Tran; S. H. Yoon; K. Pierzchalski; J. Yu; D. R. Goodlett; M. A. Kane. Use of Native Mass Spectrometry for Quantification of Protein Complex. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). June 2015 Meeting (oral presentation).

Asilomar Conference on Native Mass Spectrometry — October 2015

• W. Li, M.A. Kane. Quantitative Analysis of Noncovalent Protein Complex Through Native Mass Spectrometry; Asilomar Conference on Mass Spectrometry. (poster presentation and selected for an oral “Poster Highlight” talk)
  *Wenjing won a “Best Student Presentation” Award.

American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) — June 2015

• C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Kearney, K. Barrow, A. Gibbs, K. Kieta, C. Taylor-Howell, A. M. Farese, T. J. MacVittie, M. A. Kane. Application of MALDI-MSI to identify biomarkers of radiation-induced lung injury and medical countermeasure development. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (oral and poster presentation).
• J. W. Jones, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, C. Booth, T. J. MacVittie, M. A. Kane. Lipidomic Profiling of Plasma from Radiation Animal Models. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. National. (poster presentation).
• J. W. Jones, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, I. L. Jackson, Z. Vujaskovic, C. Booth, T. J. MacVittie, M. A. Kane. Analysis of radiation-induced injury by targeted high-throughput metabolomics. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).
• L. (J.) Wang; J. W. Jones; M.A. Kane; P. R.S. Baker. Retinoic Acid Analysis with Differential Mobility Mass Spectrometry for Improved Selectivity and Sensitivity. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).
• W. Li; B. Tran; S. H. Yoon; K. Pierzchalski; J. Yu; D. R Goodlett; M. A Kane; Use of Native Mass Spectrometry for Quantification of Protein Complex. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).

NIAID Radiation and Nuclear Group Meeting (Bethesda, MD) — May 2015

• M.A. Kane. Mass Spectrometry Imaging: Molecular Imaging and Biomarkers. NIAID RNG Meeting (Bethesda, MD). May 2015. (oral presentation).

ConRad Global Conference on Radiation (Munich, Germany) — May 2015

• J. W. Jones, C. L. Carter, F. Li, G. Tudor, A. Bennett, S. Kearney, C. Taylor-Howell, C. P. Smith, A. M. Farese, Y. Tong, B. Katz, C. Booth, T. J. MacVittie, M. A. Kane. Targeted and Discovery-based Mass Spectrometry Metabolomics for Biomarker Identification and Validation in Mouse and Non-Human Primate Radiation Models. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (oral presentation).
• C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Kearney, K. Barrow, A. Gibbs, A. M. Farese, T. J. MacVittie, M. A. Kane. Imaging Molecular Changes in the Lung Following Whole Thorax Irradiation +/- AEOL10150 treatment using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (poster presentation).
• J. W. Jones, C. L. Carter, F. Li, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Lipidomic Studies of Lung Tissue from the Whole Thorax Lung Irradiation Mouse Model: Detection, Visualization, and Quantification of Lung Lipid Biomarkers. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (poster presentation).

8^th Annual Frontiers in Chemistry and Biology Interface (Baltimore, MD) — May 2015

• D. Deredge, J. Li, K. Johnson, P. Wintrode. Conformational basis of HCV RNA-dependent RNA polymerase inhibition by allosteric Thumb II site inhibitors. 2015, 8th Annual Frontiers in Chemistry and Biology Interface. Awarded poster prize. (poster & presentation)

Experimental Biology (Boston, MA) — March 2015

• M.A. Kane. Retinoic acid biosynthesis defects in cancer. Carotenoid and Retinoid Interest Group (CARIG) Symposium prior to Experimental Biology Meeting (Boston, MA) March 27, 2015. (oral presentation).

Biophysical Society 59^th Annual Meeting (Baltimore, MD) — February 2015

• D.Deredge, K. Johnson, P. Wintrode. Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase. Biophys. 108 , Issue 2, 2015, 59^th Annual Biophysical Society meeting (poster presentation)

CMCR Workshop II: Mitigation and Treatment of Radiation Injury (Baltimore, MD) — October 2014

• C.L. Carter, J.W. Jones, M.A. Kane. MALDI-MSI to identify changes in the lipid profiles as they relate to radiation damage and mitigation.  CMCR Workshop II: Mitigation and Treatment of Radiation Injury (Baltimore, MD). October 8, 2014. (oral presentation).

Radiation Research Society. (Las Vegas, NV) — September 2014

• J. W. Jones, K. Pierzchalski, J. Yu, C. L. Carter, Fei Li, G. Tudor, A. Bennett, A. M. Farese, I. L. Jackson, Z. Vujaskovic,C. Booth, T. J. MacVittie, M. A. Kane. Metabolomic analysis reveals radiation disrupts essential nutrient signaling nodes. Radiation Research Society. (Las Vegas, NV). September 2014. (poster presentation).
• J. W. Jones, F. Li, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, Y. Tong, B. Katz, C. Booth, T. J. MacVittie, M. A. Kane. Targeted and Discovery-based Mass Spectrometry Metabolomics for Biomarker Identification and Validation in Mouse and Non-Human Primate Radiation Models. Radiation Research Society (Las Vegas, NV). September 2014. (poster presentation).
• C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Tabisz, S. Kearney, A. Gibbs, J. Harper, K. Barrow, A. M. Farese, T. J. MacVittie, M. A. Kane. Using MALDI-MSI to enable biomarker identification and medical countermeasure development for radiation-induced lung injury. Radiation Research Society, (Las Vegas, NV).  September 2014. (poster presentation).

FASEB Summer Research Conference on Retinoids/Second International Retinoid Meeting, (Itasca, IL) — June 2014

• J.W. Jones, K. Pierzchalski, J. Yu, M. A. Kane. Quantitative profiling of retinoid homeostasis.” Invited speaker at FASEB Summer Research Conference on Retinoids/Second International Retinoid Meeting, (Itasca, IL). June 2014. (oral presentation).
• J. Yu, K. Pierzchalski, J. W. Jones, M. A. Kane. Targeted metabolomic analysis to interrogate the role of cellular retinol-binding protein, type 1 in retinoic acid biosynthesis. FASEB Summer Research Conference on Retinoids/Second International Retinoid Meeting, (Itasca, IL). June 2014. (poster presentation).
• K. Pierzchalski, C. Nezhat , J. L. Napoli , G. Yang , N. Sidell , M. A. Kane. Retinoic Acid Biosynthesis is Impaired in Endometriosis. FASEB Summer Research Conference on Retinoids/Second International Retinoid Meeting, (Itasca, IL). June 2014. (poster presentation).

American Society of Mass Spectrometry Annual Meeting (Baltimore, MD) — June 2014

• C. L. Carter, J. W. Jones , I. L. Jackson , Z. Vujaskovic, S. Tabisz, A. Gibbs, J. Harper, K. Barrow, A. M. Farese, T. J. MacVittie, M. A. Kane MALDI-MSI Lipidomic Investigation into the Delayed Effect of Acute Radiation Exposure: The Lung Syndrome and the Efficacy of a Medical Countermeasure. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• D. Deredge, C. Liu, V. LiCata, P. Wintrode. Dynamic Signatures of Thermal Adaptation in DNA Polymerases Observed by Hydrogen Exchange. 2014, ASMS Conference on Mass Spectrometry and Allied Topics. June 2014. (poster presentation).
• J. W. Jones, F. Li, C. L. Carter, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Identification of Lipid Biomarkers from Mouse Lung Tissue via the Use of UPC² Tandem Mass Spectrometry. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• J. W. Jones, C. J. Thompson, C. L. Carter, G. Tudor, C. Booth, I. L. Jackson, Z. Vujaskovic, T. J. MacVittie, M. A. Kane. Electron-Induced Dissociation (EID) of physiologically relevant phospholipids and glycophospholipids. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• F. Li, J. W. Jones, G. Tudor, C. Booth, T. J. MacVittie, M. A. Kane Disruption of amino acid metabolism in radiation-induced lung injury. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• W. Li, J. W. Jones, J. Yu, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, G. Tudor, C. Booth, T. J. MacVittie, M. A. Kane. Metabolite profiling of active metabolites of vitamin A in lung epithelial cells. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• K. Pierzchalski, J. W. Jones, C. Booth, G. Tudor, A. Bennett, A. M. Farese, T. J. MacVittie, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Application of multistage tandem mass spectrometry for quantification of endogenous metabolites in lung tissue. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• B. Tran, C. Booth, G. Tudor, W. Li, Y. A. Goo, T. J. MacVittie,D. R. Goodlett, M. A. Kane Label-free quantitative analysis of radiation-induced differential protein expression in the mouse lung proteome. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).
• J. Yu, J. W. Jones, K. Pierzchalski, M. A. Kane. Targeted metabolomic analysis to interrogate the role of cellular retinol-binding protein, type 1 in retinoic acid biosynthesis. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

Waters User Meeting (Baltimore, MD) — June 2014

• J. W. Jones , K. Pierzchalski , J. Yu , C. Carter , F. Li , I. L. Jackson , Z. Vujaskovic , A. Bennett , A. M. Farese , E. Farias, T. J. MacVittie , and M. A. Kane. “Metabolomics to characterize tissue damage, dysfunction and repair” Invited seminar at Waters User Meeting at American Society of Mass Spectrometry (Baltimore, MD). June 2014. (oral presentation).

Mid-Atlantic Directors and Staff of Scientific Cores Meeting (Baltimore, MD) — June 2014

• C. L. Carter, J. W. Jones, K. Pierzchalski, J. Yu, B. Tran, W. Li, M. A. Kane. “MALDI-MSI Macromolecular Localization and Biomarker Discovery” Mid-Atlantic Directors and Staff of Scientific Cores 2014 Meeting (Baltimore). June 2014. (oral presentation).

Frontiers at the Chemistry-Biology Interface Symposium (Baltimore, MD) — May 2014

• J. W. Jones , K. Pierzchalski , J. Yu , C. Carter , F. Li , I. L. Jackson , Z. Vujaskovic , A. Bennett , A. M. Farese, E. Farias, T. J. MacVittie, and M. A. Kane. Metabolomics to characterize tissue damage, dysfunction and repair. Frontiers at the Chemistry-Biology Interface Symposium (Baltimore, MD). May 2014. (oral presentation).

M-CERSI Conference: MALDI-Mass Spectrometry Imaging of Drug Metabolism (Baltimore, MD) — April 2014

• C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Tabisz, S. Kearney, K. Barrow, A. Gibbs, A. M. Farese, T. J. MacVittie, M. A. Kane. Mass Spectrometry Imaging in the Development of Medical Countermeasures Against Radiological Threat. M-CERSI Conference: MALDI-Mass Spectrometry Imaging of Drug Metabolism (Baltimore, MD). April 2014. (oral presentation).

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD) — April 2014

• J.W. Jones, K. Pierzchalski, J. Yu, M.A. Kane. Fast HPLC and MRM³ for Retinoic Acid Quantitation in Complex Matrices: Use of targeted metabolomics to probe retinoid metabolism

Waters Metabolomics Seminar (Columbia, MD) — March 2014

• J. W. Jones, K. Pierzchalski, J. Yu, C.L. Carter, F. Li, I. L. Jackson, Z. Vujaskovic, A. Bennett, A. M. Farese, E. Farias, T. J. MacVittie, M. A. Kane. Metabolomics to characterize tissue damage, dysfunction and repair. Waters Metabolomics Seminar (Columbia, MD). March 2014. (oral presentation).

Radiation Research Society (New Orleans, LA) — September 2013

• C. L. Carter, J. W. Jones, A. J. Scott, Y. A. Goo, A. Plett, C. M. Orschell, D. R. Goodlett, R. K. Ernst, M. A. Kane. Biomarker Discovery and Validation: Coupling MALDI Imaging to Proteomic Expression and Metabolite Quantitation to Characterize Radiation-Induced Tissue Damage. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)
• J. W. Jones, A. Bennett, A. M. Farese, T. J. MacVittie, M. A. Kane. Biomarker Discovery for Radiation Induced Tissue Damage Via Un-Targeted Mass Spectrometry Based Metabolomics. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)
• J. W. Jones, G. Tudor, A. Bennett, A. M. Farese C. Booth, T. J. MacVittie, M. A. Kane. Evaluation of Citrulline as a Biomarker for Radiation-Induced Gastrointestinal Tissue Damage. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)

First International Retinoids Meeting (Calabria, Italy) — September 2013

• K. Pierzchalski , J. Yu , J. W. Jones , C. Carter , Y. A. Goo , B. Tran , A. J. Scott , I. L. Jackson , Z. Vujaskovic , C. Booth , G. Tudor , A. Plett , C. M. Orschell , R. K. Ernst , D. R. Goodlett , A. Bennett , A. M. Farese , T. J. MacVittie , and M. A. Kane. Profiling of endogenous retinoids: Radiation alters retinoid homeostasis. First International Retinoids Meeting (Calabria, Italy). September 2013. (oral presentation).
• K. Pierzchalski, M.A. Kane. Impact of CrbpI and retinoic acid on endometriosis. First International Conference on Retinoids (Calabria, Italy) September 2013. (oral and poster presentation).
• M. Perri, J. Yap, S. Fletcher, E. Cione, M.A. Kane. Combined doses of the dual Bcl-x_L/Mcl-1 inhibitor JY-1-106 and a selective RARγ antagonist work cooperatively but in different manner in human leukemia and breast cancer cells. First International Conference on Retinoids (Calabria, Italy). September 2013. (oral and poster presentation).
• K. Pierzchalski, J. Yu, J. W. Jones, C. Carter*, Y. A. Goo , B. Tran, A. J. Scott , I. L. Jackson, Z. Vujaskovic, C. Booth, G. Tudo , A. Plett , C. M. Orschell, R. K. Ernst, D. R. Goodlett, A. Bennett, A. M. Farese, T. J. MacVittie, M. A. Kane. Radiation alters retinoid homeostasis. First International Retinoids Meeting (Calabria, Italy). September 2013. (poster presentation).

NIAID Radiation and Nuclear Group Meeting (Bethesda, MD) — June 2013.

• M. A. Kane, J. W. Jones, A. Scott, G. Tudor, A. Bennett, A. M. Farese, C. Booth, C. M. Orschell, I. L. Jackson, R. K. Ernst, Z. Vujaskovic, T. J. MacVittie. Citrulline as a biomarker of radiation-induced damage and the use of mass spectrometry based techniques to characterize radiation-induced tissue damage. NIAID RNG Meeting (Bethesda, MD). June 2013. (oral presentation).

American Society for Mass Spectrometry Conference (Minneapolis, MN) — June 2013.

• J. W. Jones, A. J. Scott, K. Pierzchalski, Y. A. Goo, C. L. Carter, A. Plett, C. M. Orschell, D. R. Goodlett, R. K. Ernst, M. A. Kane. Biomarker Discovery and Validation: Coupling Mass Spectrometry Imaging to Proteomic Expression and Metabolite Quantitation to Characterize Radiation-Induced Tissue Damage. 61^st American Society for Mass Spectrometry Conference (Minneapolis, Minnesota). June 2013. (poster presentation)
• J. W. Jones, A. Bennett, G. Tudor, K. Pierzchalski, B. Q. Tran, A. M. Farese, C. Booth, T. J. MacVittie, M. A. Kane. Biomarker Discovery for Radiation Induced Tissue Damage Via Targeted and Un-Targeted Mass Spectrometry Based Metabolomics. 61^st American Society for Mass Spectrometry Conference (Minneapolis, Minnesota). June 2013. (poster presentation)

ConRad Global Conference on Radiation (Munich, Germany) — May 2013.

• J. W. Jones*, G. Tudor, C. Booth, T. J. MacVittie, M. A. Kane. Evaluation of Citrulline as a Biomarker for Radiation-Induced Gut Damage. Global Conference of Radiation Topics (Munich, Germany). May 2013. (oral and poster presentation).
  +chosen for oral presentation.

U.S. Human Proteome Organization Meeting, (Baltimore, MD) — March 2013.

• J.Jones, A. Scott, Y.A. Goo, A. Plett, C. Orschell, R.K. Ernst, D.R. Goodlett, M.A. Kane. Proteomic biomarker discovery and validation: coupling MALDI Imaging and LC ESI tandem mass spectrometry to characterize radiation-induced tissue damage. US Human Proteome Organization Meeting, (Baltimore, MD) March 2013. (poster presentation)

American Epilepsy Society Meeting, (San Diego, CA) — December 2012

• J. Wong, W. Jiang, T. Ting, J.E. Polli, M.A. Kane. A liquid chromatography-tandem mass spectrometry method for the quantification of lamotrigine in patient plasma.  American Epilepsy Society Meeting, (San Diego, CA). December 2012. (poster presentation)

Computer Aided Drug Design Center Symposium, School of Pharmacy, University of Maryland, Baltimore (Baltimore, MD) — July 2012.

• M.A. Kane. Mass spectrometry in drug design: quantitative profiling of endogenous metabolites by LC-MS/MS. Computer Aided Drug Design Center Symposium, School of Pharmacy, University of Maryland, Baltimore (Baltimore, MD). July 2012. (oral presentation).

FASEB Retinoid Summer Research Conference (Snowmass, CO) — June 2012.

• M.A. Kane. Retinoic acid biosynthesis defects in cancer: profiling endogenous retinoic acid by LC-MS/MS. FASEB Retinoid Summer Research Conference (Snowmass, CO). June 2012. (oral presentation).
• K. Pierzchalski, J. Yu, M.A. Kane. Impact of CrbpI on mammary retinoic acid homeostasis. oral and poster presentation at FASEB Summer Research Conference on Retinoids (Snowmass, CO). June 2012. (oral and poster presentation).
  +chosen for oral presentation
  ++KP awarded a Graduate Student Travel Award for this work
• J. Yu, K. Pierzchalski, M.A. Kane. RA homeostasis in mammary epithelial cells. FASEB Summer Research Conference on Retinoids, (Snowmass, CO). June 2012. International.

EMBO Retinoids Conference (Strasbourg, France) — September 2011

• M.A. Kane. Retinoic Acid Biosynthesis Defects in Cancer. EMBO Retinoids Conference, (Strasbourg, France) September 2011. (oral and poster presentation).

Experimental Biology (Washington, DC) — April 2011

• M. A. Kane, C. Shao, A. Pingitore, K. Pierchalski Quantitative assessment of endogenous retinoids in breast cancer models. Experimental Biology National Meeting – American Society for Investigative Pathology session on Neoplasia (Washington, DC). April 2011. (poster presentation)
• A. Pingitore, M. Perri, E. Cione, M. A. Kane. Altered retinoid metabolism in breast cancer. Experimental Biology National Meeting – American Society for Investigative Pathology Session on Neoplasia (Washington, DC). April 2011. (poster presentation)