The Mass Spectrometry Center at the School of Pharmacy is a proud partner in the Waters Centers of Innovation program, which recognizes analytical scientists and facilitates breakthroughs in health and life science research, food safety, environmental protection, sports medicine, and many other areas.
Dr. Maureen Kane discusses the Mass Spectrometry Center's partnership with Waters and the Center's robust research capabilities.
Waters Equipment:
The Mass Spectrometry Center is home to five Waters instruments:
- Waters ACQUITY TQD Tandem Quadrupole Mass Spectrometer with Alliance HPLC
- Waters ACQUITY TQ-XS Tandem Quadrupole Mass Spectrometer with AQUITY H-Class UPLC
- Waters SYNAPT G2Si HDMS Q-TOF Mass Spectrometer
- Waters SYNAPT G2S HDMS Q-TOF Mass Spectrometer
- Waters TQ-S Triple Quadrupole Mass Spectrometer - GLP Compliant
Waters Presentations:
2018
Mass Spectrometry: An Expanding Tool for the Biophysicist
The University of Maryland School of Pharmacy hosted a one-day symposium entitled “Mass Spectrometry: An Expanding Tool for the Biophysicist” on March 13, 2018, as part of the Biophysical Society's Annual Biophysics Week.
2017
J. W. Jones, C. Sarkar, M. M. Lipinski, M. A. Kane .Lipidomic analysis after traumatic brain injury: interrogating lysosomal damage toward understanding mechanisms of cell death. Waters: Metabolomics in Translational Research Summit (Washington, DC) July 2017.
2016:
Waters Seminar: Using HDX MS to Characterize Biomolecules, Baltimore, MD, June 2016
D. Deredge. Insights from HDX_MS into the Drug DIscovery and Development Process. Waters Seminar: Using HDX MS to Characterize Biomolecules (Baltimore, MD), June 2016 (Oral Presentation).
2014:
Waters User Meeting, Baltimore, MD, June 2014
J.W. Jones, K. Pierzchalski, J. Yu, C. Carter, F. Li, I.L. Jackson, Z. Vujaskovic, A. Bennett, A.M. Farese, E. Farias, T.J. MacVittie, and M.A. Kane. “Metabolomics to characterize tissue damage, dysfunction and repair.” Invited seminar at Waters User Meeting at the American Society of Mass Spectrometry (Baltimore, MD), June 2014 (Oral Presentation).
Waters Metabolomics Seminar, Columbia, MD, March 2014
J.W. Jones, K. Pierzchalski, J. Yu, C.L. Carter, F. Li, I.L. Jackson, Z. Vujaskovic, A. Bennett, A.M. Farese, E. Farias, T.J. MacVittie, M.A. Kane, "Metabolomics to characterize tissue damage, dysfunction and repair." Waters Metabolomics Seminar (Columbia, MD), March 2014 (Oral Presentation).
Other Waters News:
Waters Thought Leader Forum:
Maureen Kane, PhD, professor in the Department of Pharmaceutical Sciences (PSC) and director of the Mass Spectrometry Center, was recently invited to attend the Waters Thought Leader Forum held at Waters headquarters in Manchester, UK. The event included more than two days of discussion on the cutting-edge applications and the direction of current trends in mass spectrometry.
Introduction of Good Laboratory Practice (GLP)-Compliant Bioanalysis:
Good Laboratory Practice (GLP) for Nonclinical Laboratory Studies Regulations (21 Code of Federal Regulations (CFR) Part 58) are regulations that pertain to all nonclinical laboratory studies submitted in support of a research or marketing application for a FDA-regulated product. The Mass Spectrometry Center recently acquired a Waters TQ-S coupled to a Waters I-Class UPLC that is devoted to GLP bioanalysis.
The Center now offers GLP-regulated bioanalysis for studies requiring this regulatory compliance:
- Analytical methods are validated according to FDA Guidance for Bioanalytical Method Validation
- LC-MS/MS based assays performed under GLP regulations
- Analysis of drug compounds and metabolites
- Method transfer from literature
- Custom LC-MS/MS assays for analytes of interest
- QA/QC surveillance and compliance
Inquiries should be directed to massspec@rx.umaryland.edu.
