Requirements

NONMEM® is a non-linear mixed effects modeling software tool used in population pharmacokinetic- pharmacodynamic analysis. This section explains the procedure to develop a population PK or PKPD model for the problem given in case studies.

We have assumed the following things before any user uses this section:

  • NONMEM V is installed on the PC.
  • Since the tutorial section uses Wings for NONMEM, it is recommended to work using Wings for NONMEM and it can be downloaded from http://wfn.sourceforge.net/
  • FORTRAN compiler is installed on the PC.

A NONMEM run requires the following

  • Data file: User supplied text file containing all data for analysis. The file is created with a '.csv' or '.prn' extension.
  • Control stream: User-written and supplied modeling instruction file for NONMEM. The file is created with a '.ctl' extension using any text editor.

Modeling process

It is assumed that the following two steps are performed before proceeding to modeling.

  • The project plan is specified a priori.
  • Initial preliminary data analysis has been performed and rough initial estimates are obtained.

Click on the links below for a step by step modeling process of case studies.